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TB-500 is reported to act systemically, mobilising and directing reparative cells throughout the bodys tissues

Mouse strains IFN -/- or IFN R -/- mice were bred and maintained by the Biological Research Facility at The Francis Crick Institute

Immunohistochemical staining (IHC) A HCC tissue microarray containing 10 pairs of tumor tissues and matched adjacent tissues (HLivH020PG01) and a PCa tissue microarray containing 3 normal tissues, 8 adjacent tissues and 49 tumor tissues (HProA060PG01) were purchased from Outdo Biotech (Shanghai, China)

Isoprenoids, in turn, are involved in the activation of the Rho/ROCK pathway, which is responsible for the development of fibrosis, inflammation, and vascular damage