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Its pivotal trial enrolled 816 participants and met its primary efficacy endpoint, supporting FDA approval in 2010 with documented visceral fat reductions of roughly 15-18% over 26 weeks
Dissociative anesthetics, including ketamine and nitrous oxide, impair glutamatergic transmission and mitochondrial function, thereby exacerbating excitotoxicity and neuronal apoptosis
Folate may worsen anxiety, agitation, insomnia or obsessive symptoms in susceptible patients
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