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2-D electrophoresis was performed to elucidate the reasons for this discrepancy, and the results indicated obvious changes in central metabolism and amino acid metabolism in the penta-mutant
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In the ECHO-202/KEYNOTE-037 trial, epacadostat combined with the PD-1 inhibitor perbrolizumab showed extensive anti-tumor activity against a variety of cancer types (Mitchell et al., 2018)
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