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PubMed 16583442 Chang CH, et al

The first line of defense against superoxide is the presence of a specific member of the family of metalloenzymes called superoxide dismutases (SODs), MnSOD or SOD2, specifically located in the mitochondrial matrix, which catalyzes the dismutation of superoxide anion into H 2 O 2 as shown in Figure 2

These data suggest that GSH synthesis, potentially through NRF2 repression, also limits NRF1 protein expression in the liver

For example, astaxanthin supplementation has been shown to result in significant reductions in liver enzymes such as ALT and AST in clinical trials, reflecting improved liver health and function