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Gabery S, Salinas CG, Paulsen SJ, et al

In the intestine, valproate glucuronide may be metabolized back into valproic acid by acylpeptide hydrolase which is then absorbed into the blood

Nat Immunol (2018) 19(5):47586

The ARC, a key site of the hypothalamus, receives direct signals from the periphery, and it contains both orexigenic neurons expressing Agouti-related peptide (AgRP)/NPY and anorexigenic neurons expressing POMC (27)