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Among the 4 high-grade serous epithelial ovarian cancer (HGSOC) cell lines: OV1369(R2), OV90, OV4453, and OV1946, the percentage of dead tumor cells after treatment with olaparib (10M) and ABT-263 (0.25 M for OV1369(R2) and 2.5 M for other cell lines) exceeded 75% [137]
That said, deficiency is rare and can only be confirmed through a lab test
Presented for research literature review only Tucci JR et al
Half-life ~30 min plasma half-life reported in rat models (subcutaneous administration)
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