Reported Cymbalta discontinuation symptoms include: Agitation Anxiety Brain zaps (electrical shock sensations in the brain) Diarrhea Dizziness Excessive mood changes Fatigue Headache Insomnia Nausea Seizures Suicide Vomiting A qualitative analysis published in Therapeutic Advances in Psychopharmacology stated, It is now suspected that antidepressant withdrawal syndrome is more common and severe than earlier presumed, affecting roughly 30%-50% of those who attempt to stop their treatment. The analysis also reported that some people experience debilitating withdrawal symptoms, pointing to the link between withdrawal and suicide
That said, staying on semaglutide is a decision you should make with your provider based on your health goals, how you respond to treatment, and whether the benefits continue to outweigh any side effects
While previous fiber photometry results showed that administration of GLP-1 or liraglutide did not significantly alter ARC AgRP/NPY neuron calcium signals post 30-minute injection, after 2 hours post-injection, the rapid suppression of AgRP calcium signals after cognition of food was indeed attenuated by liraglutide [49,82,85]
van Rumund A, Green AJE, Fairfoul G, Esselink RAJ, Bloem BR, Verbeek MM
