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Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohns Disease and Obesity or Overweight (COMMIT-CD)
Note: animal studies indicate that high doses of DPP-4 inhibitors & GLP-1 agonists cause expansion of cells of the pancreatic ductal glands and can cause premalignant pancreatic intraepithelial lesions (PanIN) that have the potential to progress to pancreatic adenocarcinoma
These findings suggest that optimal NAMPT levels and activity are critical for healthy aging and overall organismal homeostasis, and both upregulation and targeted inhibition may offer potential interventions depending on the specific context and tissue
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