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Consistently, the STEP (Semaglutide Treatment Effect in People with Obesity) trial [22] demonstrated that after 68 weeks of semaglutide therapy in individuals who are overweight or obese, the average weight loss achieved was 14.9%, with 86.4% of participants achieving a reduction of at least 5% from baseline, and 69.1% and 50.5% achieving reductions exceeding 10% and 15%, respectively
Long-term success requires sustained commitment to healthy habits and regular medical supervision.
As of February 2026, Eli Lilly plans to submit orforglipron for FDA approval as a diabetes treatment sometime in 2026
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