Anyone can develop a vitamin B12 deficiency
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And a few, particularly those related to Akkermansia muciniphila , raise legitimate safety questions that deserve serious attention, especially for people with autoimmune conditions, compromised immune systems, or inflammatory bowel disease
Furthermore, the DTI metrics that are used as proxies of myelin integrity do not specifically identify myelin abnormalities, but detect differences in water diffusiona parameter that can be altered by axon packing density, axon caliber, and more confounding factors (Chang et al., 2017)