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The ions and small molecules move across the IMM following the concentration gradient

Experimental models frequently employ the natural neurotoxin kainic acid to trigger excitotoxic neuronal death, providing a well-established paradigm for studying neurodegeneration [98]

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This is consistent with prior studies, and a system review reported that ADRs of GLP-1 RAs tend to arise from the gastrointestinal system, with nausea, diarrhea, and vomiting occurring in up to 51%, 20%, and 19% of patients, respectively ( In our study, semaglutide had the highest risk for nausea (ROR, 7.41