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J., Higgins, S

The adjusted difference in mean DBP (mm Hg) change between groups was 4.2 mm Hg, (95% CI 8.8 to 0.3, P = 0.068) (Table 2)

Bactrim contains sulfonamide (a molecule composed of sulfur, oxygen, nitrogen, and hydrogen), and an allergic reaction to this medication is not due to the chemical makeup of sulfonamide, but rather the mechanism of action of the drug