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Use synthetic immunosuppressive agents (e.g., azathioprine, cyclophosphamide, leflunomide, methotrexate, mycophenolate) mainly as glucocorticoid-sparing agents in patients requiring long-term glucocorticoid therapy (i.e., those with severe organ impairments)
By optimizing the formulation, it is possible to enhance brain uptake by more than 10 folds [93]
Integrating the RNAseq with the proteomics data, focusing specifically on downregulated genes/proteins, we identified 11 genes that exhibited alterations at both the transcriptional and protein levels (Fig
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