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By regulating MITF transcription, the Wnt/-catenin signaling pathway can control the expression of TYR and other pigmentation enzymes

A: Many people use hydroquinone for about 8 to 12 weeks at a time

**Other Indications:** May be used as part of a treatment regimen for certain metabolic disorders or conditions that require vitamin B12 supplementation

2 T2DM causes changes in cognitive function 2.1 Cognitive impairment in T2DM: stages and risk factors In individuals with T2DM, cognitive functioning undergoes distinct stages of impairment, ranging from diabetes-associated cognitive decrements to MCI and dementia (Tamura et al., 2017)