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We review recommendations that have been published to date, and consider the best availablebut currently limitedevidence from large observational studies and the DARE-19 randomized control trial
Most common: nausea, vomiting, diarrhea (usually mild and resolve with titration)
A monomolecular coagonist (tirzepatide) of receptors for both incretin hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide) produced HbA1c values below 5.7% in 50% of the treated patients and weight losses exceeding 20% in obese individuals
Predictive factors for HbA1c and weight loss associated with semaglutide treatment in type 2 diabetes mellitus: real-world clinical evidence
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