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This "energy sink" literally starves the brain, heart, and skeletal muscles of energy, directly causing the hallmark symptom of post-exertional malaise (PEM) and the severe exercise intolerance seen in these conditions

doi: 10.1016/j.plaphy.2018.05.025 51 SzabadosL.SavoureA

The variation between analyses of material from the same filter may indicate that RuBisCO was not homogeneously distributed throughout the sample that may contribute a significant number of highly effective INPs active at warm temperatures