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However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)
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Total gastrectomy always produces vitamin B12 deficiency
Retinol activates nuclear retinoic acid receptors and drives collagen gene transcription, but frequently causes irritation, peeling, and photosensitivity at therapeutic concentrations
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