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doi: 10.1002/cyto.990020515 190 HudsonCCLiuMChiangGGOtternessDMLoomisDCKaperFet al

Scharf, Tingjun Hou, Tianhua Zhou, Ming-Wei Wang, Yan Zhang URL: Published: Cell Research, 25 August 2021, volume 31, pages 11631175 This study reports four high-resolution structures of full-length melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein stimulated by different ligands, including the FDA-approved drug bremelanotide (Vyleesi)

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For example, releasing a tethered scar may improve indentation but not address excess skin, while repairing muscle separation may improve abdominal support but leave a visible lower fold if skin laxity is present