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The mechanism probably involve an effect of FLNA in regulating lysosomal degradation of SSTR2, since SST2 ligand-induced down-regulation was abolished when lysosomal degradation was prevented
Furthermore, microinjections of leptin in rodents, into the ventromedial hypothalamus (VMH) 21 and the arcuate nucleus (ARC) 22 can decrease food intake massively, suggesting that leptins actions are mediated mainly by the hypothalamus
Higher doses or more frequent treatments typically lead to higher costs
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