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Key proof-of-principal study that shows that continuous subcutaneous infusion of GLP-1 improves glycaemic control in patients with T2DM

Three changes distinguish it from the native fragment: a lactam bridge between the Asp5 side-chain carboxyl and the Lys10 side-chain amine, inversion to D-phenylalanine at position 7, and norleucine in place of the oxidation-prone methionine at position 4

If the results are slow, speak with your doctor, and they will give you advice on what to do next