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It is unknown whether WEGOVY causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined [see Warnings and Precautions ( 5.1 ) and Nonclinical Toxicology ( 13.1

GIP receptor agonism adds incremental insulin sensitization in adipose tissue and may improve GI tolerability relative to pure GLP-1 agonism at equivalent doses, though the clinical net effect on tolerability varies by individual [6]

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Peak plasma concentration timing also varies