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Corticosteroid injections: Effective for pain relief but associated with collagen fiber weakening and increased re-injury risk with repeated administration

WangYLiCWuFMaoJZhuJXieHet alThe negative effects of extracellular vesicles in the immune system

Abbreviations NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis DNL: De-novo lipogenesis TNF: alphaTumour necrosis factor APN: Adiponectin HCC: Hepatocellular carcinoma MS: Metabolic syndrome FFA: Free fatty acids ACC: Acetyl COA carboxylase SREBP: 1Sterol regulatory element binding protein ChREBP: Carbohydrate response element binding protein ER: Endoplasmic reticulum MHC: Major histocompatibility test ETC: Electron transport chain SODS: Superoxide dismutase GSH: Growth stimulating factor LCFAS: Long chain fatty acids PUFA: Polyunsaturated fatty acids LDs: Lipid droplets TGs: Triglycerides References Yi J, Pan J, Zhang S, Mao W, Wang J, Wang W, Yan Z (2022) Improvement of chronic non-bacterial prostatitis by Jiedu Huoxue decoction through inhibiting TGF-/SMAD signaling pathway

For topical formulations, concentrations of 0.1 to 0.3 percent are used, with efficacy detectable from as low as 0.01 percent