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551,552 Clinical progress and challenges At present, there are more and more clinical trials regarding mitochondria-targeted therapies, covering different disease directions, especially diseases related to mitochondrial dysfunction, such as cancers, motor muscle diseases, neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and rare mitochondrial diseases
DSIP flux across the BMEC monolayers was also found to be bidirectional, insensitive to metabolic inhibitors, and not altered by high concentrations of tryptophan
