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did not directly point out the treatment potential of GLP-1R agonists for DPN, these results may support the peripheral neuroprotective effect of GLP-1R agonists considering the close association of DPN with adverse limb events (60)
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The primary function of the GLP-1R is to bind the GLP-1 protein and its analogs and initiate signaling inside pancreatic -cells to release insulin
Following GLP-1 RA initiation at the lowest dose with subsequent titration, the basal insulin dose can then be titrated based on clinical response and as informed by blood glucose monitoring (BGM) data
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