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What Lilly did say is that retatrutide showed significant improvements from baseline in certain cardiometabolic risk markers, including: waist circumference non-HDL cholesterol triglycerides systolic blood pressure and high-sensitivity C-reactive protein (hsCRP) 1 That is a meaningful positive finding

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In people with obesity, particularly in cases of rapid or marked weight reduction, the decline in lean mass may account up to 2530% of the total weight loss, contributing to the so-called sarcopenic obesity [18]