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KPV anti-inflammatory research has consistently shown NF-B pathway inhibition in epithelial cell models, with published data demonstrating 4565% reduction in pro-inflammatory cytokine secretion following KPV treatment

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Methods We searched PubMed, Embase, Cochrane and ClinicalTrials.gov up until 27 October 2021 for randomised controlled trials with a duration of at least 12 weeks that compared once-weekly tirzepatide 5, 10 or 15 mg with placebo or other glucose-lowering drugs in adults with type 2 diabetes irrespective of their background glucose-lowering treatment