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Further accumulation of uremic toxins, which leads to uremic syndrome, can, among others, cause neurotoxicity, disruption in the BBB integrity, oxidative stress, neuroinflammation, and disturbance of brain neurotransmitter amino acids balance (Hamed, 2019)
In vitro , overexpression of DsbA-L decreases the injury of HG and palmitic acid treated HK-2 cells by directly interacting with catalase (72)
Additionally, compared to the tumors of mice without drug treatment and those treated with Ru(II)-OH (64.4%) and NP2 (73.6%), the tumors of mice treated with NP4 (81.2%) exhibited a higher proportion of mature DCs (CD80 + CD86 + ) (Supplementary Fig
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