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The naturally occurring ligands for PPAR- are leukotriene B 4 (LTB 4 , see the Eicosanoid Metabolism: Prostaglandins, Thromboxanes, Leukotrienes, and Lipoxins page), unsaturated fatty acids and oxidized components of VLDL and LDL
The rationale for using multiple chelators is so the individual dose of each agent can be lower, which reduces the risk of adverse events without decreasing clinical efficacy (Grady 2012)
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