Improved client-side prediction to reduce "ghost shots"
Hyperuricemia continues to be inadequately managed, primarily due to factors such as ineffective dosing of urate-lowering therapy, patient noncompliance, and intolerance/adverse events associated with current treatment options
For instance, rapamycin-mediated inhibition of mTORC1 has been shown to reduce age-related cancers [19, 20] and age-related declines in cognitive function [21, 22], and to improve heart function [2325], immune function [26], kidney function [27], oral health [28, 29], intestinal function and gut dysbiosis [30, 31], and ovarian function [32] in aging mice
While various cell membrane lipids may undergo oxidation, the peroxidation of polyunsaturated fatty acids (PUFAs) in phospholipids by lipoxygenases (ALOXs) appears to be particularly important for ferroptosis [23]