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Fat-free mass is metabolically more active per kilogram than fat tissue, so its loss disproportionately reduces resting metabolic rate going forward
In mouse models of highfat dietinduced obesity, it treatment significantly reduced mRNA and protein expression of TNF, IL6, and other inflammatory factors in adipose tissue and decreased macrophage infiltration - a hallmark of adipose inflammation
Regular supplementation helps prevent neurological symptoms linked to deficiency
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