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S-nitrosylation involves covalent attachment of nitric oxide (NO) to cysteine thiols, forming reversible S-nitrosothiols (SNOs) (Wolhuter and Eaton, 2017)

Studied together, they're meant to model how the pituitary responds to combined GHRH + ghrelin signaling

MSM can also prevent cartilage from breaking down, protecting joints from damage