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This is a large, carefully designed observational study not a randomised trial so it points to a promising signal rather than a proven benefit
(43(2)):290-296 doi:10.1002/jimd.12158
While these trials used different populations and durations, the magnitude difference has driven clinicians to consider tirzepatide when patients plateau on semaglutide
To use the language of diet book doctors, the drug makes the body shift into a fat-burning mode (as shown by the drop in RER), which then: Feeds the system from within, making the stored fat available for oxidation, which Suppresses appetite indirectly, and Attenuates the usual energy-conserving adaptations that go with calorie-restricted diets and weight loss
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