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The useful analytical framework is to ask: what is the net present value of revenues the innovator can defend after patent expiry, given realistic lifecycle management success rates, biosimilar/generic competition timelines, and payer formulary dynamics
Source: Arrone, et al New England J of Medicine May 11, 2025 Researchers randomized about 1,500 people with obesity and without diabetes to be treated with either tirzepatide or semaglutide, both at the highest tolerable recommended doses, and followed them for 72 weeks
It also plays an important role in a person's genetic components like the DNA and RNA of the egg and the sperm
Slows gastric emptying and promotes satiety Mainly active after meals
