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Aerobic training can improve fatty acid oxidation, enhance muscle metabolism, regulate insulin sensitivity, and improve amino acid and iron homeostasis, thereby mitigating the adverse effects of ferroptosis

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Future studies are needed to further elucidate the underlying mechanisms and validate our findings in larger multicenter cohorts

Constipation was assessed by frequency of defecation, response to laxatives and feces forms which were classified according to Bristol stool scale, (type 1 = separate hard lumps) (type 2 = sausage shaped and lumpy) (type3 = sausage shaped with cracks on its surface) (type 4 = sausage or snake with smooth surface) (type 5 = soft blobs) (type 6 = fluffy pieces) (type 7 = entirely liquid) 17