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HRT Addresses: Estrogen-driven fat redistribution, muscle loss prevention, sleep disruption, hot flashes and night sweats GLP-1 Addresses: Appetite dysregulation, insulin resistance, blood sugar instability, inflammation reduction Combined Benefit: Targets both hormonal AND behavioral factors, which can help preserve lean mass while losing fat and support better energy for lifestyle changes, leading to comprehensive quality of life improvement Rather than competing approaches, hormone optimization therapy and GLP-1 therapy can work through distinct physiological pathways that reinforce each other

Antibiotic mixture administered in NOD/ShiLt mice pre-EAE improved the disease course, correlated with enhanced Tregs and altered gut microbiota in Peyer's patches (Colpitts et al., 2017)

Sedlak J, Lindsay RH (1968) Estimation of sulfhydryl groups in tissue with Ellmans reagent

A.-T., Frohlich, B., Mininberg, D