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3.1 Alternative nutrient-sensing mechanisms Some nutrients stimulate intestinal hormone secretion independent of taste receptors, via pathways involving other GPCR or nutrient transporters (95, 96): Stomach: Calcium-sensing receptor (CaSR) and GPRC6A detect a broad range of amino acids and calcium, promoting gastrin and somatostatin release (89, 97)
24PerryHE, ShannonMW
Given that PCOS is frequently comorbid with steatotic liver disease and hypertriglyceridemia, we recommend intensified screening for gallbladder symptoms (e.g., right upper quadrant pain, fatty food intolerance) and regular monitoring of hepatobiliary markers during phases of rapid weight loss
Scenario 1: Healthy individual starting semaglutide with normal baseline b12 A 45-year-old with no health conditions starts semaglutide for weight loss
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