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Many studies have shown a U- or J-shaped relationship between BMI and mortality, where lower and higher BMI are associated with increased mortality risk compared to normal weight BMI levels (defined as a BMI between 18.5 to 25 kg/m)
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Nat Rev Mol Cell Biol 2005
One such side effect is loss of "lean mass" -- body weight that isn't fat -- raising concerns that Ozempic could be reducing muscle mass and strength
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