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Vandamme (Ed.), Biotechnology of Vitamins, Pigments and Growth Factors (pp
The osteosarcoma TME is characterized by dense infiltrates of immunosuppressive cells, including tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), as well as physical barriers formed by cancer-associated fibroblasts (CAFs) and a dense extracellular matrix (ECM) that restrict cytotoxic T cell infiltration (1012)
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