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Sermorelin and Tesamorelin both act on the same GHRH receptor, but Tesamorelin is more clinically validated for the visceral-fat-reduction indication and produces more consistent reductions in deep abdominal fat in studies

Notably, lactate-primed lysine acetyltransferase 8 directly lactylates mitochondrial phosphoenolpyruvate carboxykinase 2 at K100, thereby enhancing its kinase activity and reprogramming mitochondrial fatty-acid synthesis to promote ferroptotic processes (118)