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The question is never "animal model or computer model." It is "which model for which question at which stage." Every regulatory submission, every go/no-go decision, every safety signal requires a defined Context of Use
The longer the gap in treatment, the bigger the jump in risk up to a 22% increase for heart attack, stroke and death after two years off GLP-1s, largely erasing the cardiovascular benefits gained during treatment
Journal of Agricultural and Food Chemistry, 63(3):957962
The 1997 Thorner review compiled the broader GHRH-and-GHRP therapeutic-research framework (PMID 9238854)
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