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GLP-1R is expressed in dorsal root ganglion (DRG) neurons 40 and could explain the potential direct effect on pain in OA since DRG neuron endings are present in the synovium 41

This research was supported by a faculty start-up fund from Pennsylvania State University, NSF CAREER IOS-2144082, the USDA National Institute of Food and Federal Appropriations under Hatch Project #PEN04770 and Accession #1010058