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High GSH concentrations in the reaction mixtures even slightly decreased the rate constants, suggesting a competition for the 1 st glutathione-interaction site (Fig

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Some approximate equivalencies have emerged from clinical observation, though these should guide rather than dictate dosing decisions

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Embedding of alkyl bromide warheads into non-covalent inhibitors enables covalent modification of a glutamate in the lipoprotein binding chaperone - phosphodiesterase of retinal rod subunit delta (PDE), which shuttles prenylated lipoproteins between cellular membranes and thereby mediates their activity

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