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Clinical trials demonstrate that gradual escalation produces superior long-term weight loss and adherence compared to rapid dose jumps
Curr Microbiol
Accordingly, monitoring of total concentrations may be misleading since free concentrations may be substantially elevated in patients with hepatic disease whereas total concentrations may appear to be normal [seeBoxed Warning,Contraindications (4), andWarnings and Precautions (5.1)]
At standard therapeutic doses (5mg and above), the difference between rounding up and down is clinically insignificant
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