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As to the fate of those spontaneously-activated MuSCs in female Keap1 cKO mice, GSEA showed that the term of myogenesis, which includes many differentiation-related genes (e.g., Myh1/3/9 , Tnnc1 , and Tnni1/2 ), was only enriched in Keap1 -null MuSCs from female mice (Supplementary Fig
But it has to be done with common sense and appropriate medical supervision. For patients considering or currently using GLP-1 medications, the key takeaway is balance: embrace the health benefits, but stay in close communication with your healthcare team to ensure safe, effective results
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