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The GP reaction is: 2GSH + H 2 O 2 GS-SG + 2H 2 O where GSH represents reduced monomeric glutathione, and GS-SG represents glutathione disulfide
Now, this synthesis vary for each vitamin B type
In AD models, Nrf2 deficiency exacerbates oxidative stress, leading to increased lipid peroxidation and DNA damage, particularly in astrocytes, which accelerates neurodegeneration and inflammation
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