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Acute paracetamol (acetaminophen) overdose is the clearest clinical demonstration of glutathione's hepatic importance: paracetamol toxicity depletes hepatic GSH, causing liver damage, and N-acetyl cysteine (NAC) a GSH precursor is the established antidote
However, there are two patented active ingredients that stabilise the methylfolate and thus drastically increase bioavailability
While we are hard-wired for stories as humans (which is why anecdotes are so compelling!), it turns out a random spattering of stories is often not enough information
Further analysis confirmed that FOXO4-positive cells co-expressed Leydig cell markers, specifically StAR and CYP11A1, indicating that FOXO4 is indeed expressed in human Leydig cells [1]
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