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Presented for research literature review only Tian Y et al
52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA
While they deliver rapid results , their effects are short-lived, often leading to stress reactions and the need for multiple costly injections
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