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Our results found that the AtABI1/2 and AtRAB18 were downregulated in OE lines under normal conditions and cold stress, which suggested that RcGPX4 impaired freezing tolerance in transgenic plants partly via the ABA-dependent pathway

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"Furthermore, this would establish intracranial pressure control as one of the mechanisms underlying migraine that can be pharmacologically targeted." Braca added that they plan to conduct a double-blind, randomized, placebo-controlled study, as this is a pilot, exploratory study