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Severe abdominal pain whilst taking GLP-1 medications requires urgent medical attention due to potential pancreatitis or gallbladder complications

After considering all of these factors, Rezaie and his colleagues found that patients using GLP-1RA medications had a statistically significant 33% higher chance of experiencing aspiration pneumonia than non-users (0.83% vs 0.63%) with a hazard ratio (HR) of 1.33

Patients may also adapt to smaller stomach capacity over time

These cumulative costs rival or exceed metabolic surgery for obesity, which provides permanent anatomical changes without ongoing medication costs