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However, recent results from a Phase III study evaluating the safety and efficacy of selonsertib, an investigational, once daily, oral inhibitor of apoptosis signal-regulating kinase 1 (ASK1), for patients with bridging fibrosis due to nonalcoholic steatohepatitis (NASH), did not meet its primary endpoint of improvement in fibrosis without worsening of NASH

Akif A, Islam MR

Excess body fat can disrupt hormone balance by converting testosterone into estrogen, lowering sperm count, and increasing inflammation a condition sometimes referred to as obesity-related hypogonadism